RESUMO
A 1-year prospective study in 2 paediatric outpatient clinics in Sousse, Tunisia, aimed to determine the presence of group A streptococci in acute pharyngitis cases and carriers, and the distribution of the serotypes and biotypes. Group A streptococci were found in 9.0% of throat swabs from 155 controls and 17.7% from 474 patients (P < 0.05). Of 43 strains isolated from patients and submitted for typing, 15 different types were identified, the most common being M75 (14 strains; 32.5%), M9 (6 strains; 14.0%), M76 (5 strains; 11.6%) and M12 (4 strains; 9.3%). Three strains were non-typeable (7.0%). Biotyping of the strains showed 3 predominant biotypes: biotype 3 (n = 14), biotype 2 (n = 11), and biotype 1 (n = 7).
Assuntos
Faringite/microbiologia , Infecções Estreptocócicas/microbiologia , Streptococcus pyogenes , Doença Aguda , Instituições de Assistência Ambulatorial , Portador Sadio/epidemiologia , Portador Sadio/microbiologia , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Estudos Epidemiológicos , Humanos , Faringite/epidemiologia , Vigilância da População , Estudos Prospectivos , Estações do Ano , Sorotipagem , Infecções Estreptocócicas/epidemiologia , Streptococcus pyogenes/classificação , Tunísia/epidemiologia , Saúde da População Urbana/estatística & dados numéricosRESUMO
A 1-year prospective study in 2 paediatric outpatient clinics in Sousse, Tunisia, aimed to determine the presence of group A streptococci in acute pharyngitis cases and carriers, and the distribution of the serotypes and biotypes. Group A streptococci were found in 9.0% of throat swabs from 155 controls and 17.7% from 474 patients [P < 0.05]. Of 43 strains isolated from patients and submitted for typing, 15 different types were identified, the most common being M75 [14 strains; 32.5%], M9 [6 strains; 14.0%], M76 [5 strains; 11.6%] and M12 [4 strains; 9.3%]. Three strains were non-typeable [7.0%]. Biotyping of the strains showed 3 predominant biotypes: biotype 3 [n = 14], biotype 2 [n = 11], and biotype 1 [n = 7]
Assuntos
Doença Aguda , Instituições de Assistência Ambulatorial , Portador Sadio , Distribuição de Qui-Quadrado , Pré-Escolar , Streptococcus pyogenes , Saúde da População Urbana , FaringiteRESUMO
To determine the role and importance of beta-haemolytic streptococci in acute pharyngitis and its relative susceptibility to antibiotics, we cultured samples from 143 patients (age range: 3-72 years) who presented over a 5-month period in 2001 at three primary health care centres in Sousse, Tunisia. The cultures yielded 80 beta-haemolytic streptococci (59 group A streptococci and 21 non-group A streptococci). All strains were susceptible to benzylpenicillin, amoxicillin, chloramphenicol, rifampicin and pristinamycin. Susceptibility was variable in erythromycin, tetracycline, fosfomycin, telithromycin and levofloxacin. Minimum inhibitory concentrations were determined by E-test for penicillin, erythromycin and levofloxacin. Our results confirm that penicillin is still the reference treatment for acute pharyngitis. However, to minimize the potential for complications arising from its use, continued vigilance is required.
Assuntos
Faringite/microbiologia , Infecções Estreptocócicas/complicações , Streptococcus pyogenes , Doença Aguda , Adolescente , Adulto , Distribuição por Idade , Idoso , Antibacterianos/uso terapêutico , Criança , Pré-Escolar , Farmacorresistência Bacteriana , Humanos , Incidência , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Seleção de Pacientes , Vigilância da População , Prevalência , Infecções Estreptocócicas/tratamento farmacológico , Infecções Estreptocócicas/epidemiologia , Infecções Estreptocócicas/microbiologia , Tunísia/epidemiologiaRESUMO
To determine the role and importance of beta-haemolytic streptococci in acute pharyngitis and its relative susceptibility to antibiotics, we cultured samples from 143 patients [age range: 3-72 years] who presented over a 5-month period in 2001 at three primary health care centres in Sousse, Tunisia. The cultures yielded 80 beta-haemolytic streptococci [59 group A streptococci and 21 non-group A streptococci]. All strains were susceptible to benzylpenicillin, amoxicillin, chloramphenicol, rifampicin and pristinamycin. Susceptibility was variable in erythromycin, tetracycline, fosfomycin, telithromycin and levofloxacin. Minimum inhibitory concentrations were determined by E-test for penicillin, erythromycin and levofloxacin. Our results confirm that penicillin is still the reference treatment for acute pharyngitis. However, to minimize the potential for complications arising from its use, continued vigilance is required
Assuntos
Doença Aguda , Distribuição por Idade , Antibacterianos , Pré-Escolar , Farmacorresistência Bacteriana , Incidência , Testes de Sensibilidade Microbiana , Seleção de Pacientes , Infecções Estreptocócicas , FaringiteRESUMO
We report 3 cases of juvenile myasthenia in 2 girls and 1 boy, who at onset, were respectively 21 months, 13 yr and 4 and a half yr old. Clinical features were common but in 2 cases included acute respiratory failure leading to artificial ventilation. Thymectomy was performed in 1 girl with thymoma who presented a vitiligo 5 yr later.
